Qiong Guo
Rochester
Summary
Accomplished researcher with advanced expertise in structure‑based discovery, leveraging Cryo‑EM, X‑ray crystallography, and complementary structural techniques to drive therapeutic innovation across multiple disease areas. Skilled in protein expression, purification, and characterization of complex biomolecular systems, with strong grounding in DNA damage repair , ubiquitin pathways, and RNA biology to inform target validation and mechanism‑of‑action studies. Experienced collaborator working across multidisciplinary teams , with a proven record of leading research strategy, and contributing to publications, conference presentations, and intellectual property development.
Overview
4
4
years of professional experience
Work History
Postdoctoral Research Fellow
Mayo Clinic
Rochester, MN
08.2025 - Current
- Identify the structural and biochemical differences between regular nucleosome and its variants.
- Explore the mechanisms of variants nucleosome ubiquitylation with different binding partners such as BRCA1-BARD1 involved in DNA damage cancer.
- Investigate how histone ubiquitylation variants recruits different histone chaperones complex by Cryo-EM or biochemical study.
Postdoctoral Research Fellow
National Institutes of Health
Bethesda, MD
10.2021 - 08.2025
- Executed detailed studies in biochemistry and cryo-EM to enhance understanding of human DNA repair polymerase zeta.
- Analyzed interactions between key partner proteins and human DNA repair polymerase to identify viable targets for drug development.
- Investigated mechanisms of DNA replication disease by focusing on reconstitution of simplified replisome in vitro.
Education
Ph.D. - Biochemistry And Molecular Biology
University of Science And Technology of China
Anhui, China 06.2021
Bachelor of Science - Biotechnology
Anhui Normal University
Anhui, China 06.2014
Skills
- Experience with multi-step protein purification techniques
- Proficient in structural techniques for analyzing protein-drug complexes
- Skilled in using CryoSPARC, ChimeraX, and Coot for structural analysis
- Conference presentation and publication skills
Timeline
Postdoctoral Research Fellow
Mayo Clinic
08.2025 - Current
Postdoctoral Research Fellow
National Institutes of Health
10.2021 - 08.2025
Ph.D. - Biochemistry And Molecular Biology
University of Science And Technology of China
Bachelor of Science - Biotechnology
Anhui Normal University